Feliform carnivores have a distinguished constitutive innate immune response

Feliform carnivores have a distinguished constitutive innate immune response

Determining the immunological phenotype of endangered and threatened populations is important to identify those vulnerable to novel pathogens. Among mammals, members of the order Carnivora are particularly threatened by diseases. We therefore examined the constitutive innate immune system, the first line of protection against invading microbes, of six free-ranging carnivore species; the black-b...

Cheetahs have a stronger constitutive innate immunity than leopards

As a textbook case for the importance of genetics in conservation, absence of genetic variability at the major histocompatibility complex (MHC) is thought to endanger species viability, since it is considered crucial for pathogen resistance. An alternative view of the immune system inspired by life history theory posits that a strong response should evolve in other components of the immune syst...

Induction of Innate Immune Response

Asthma PATHOPHYSIOLOGY Asthmatic Bronchial Epithelial Cells Have a Deficient Innate Immune Response to Infection With Rhinovirus

METHODS. BECs were cultured from bronchial brushings obtained by bronchoscopy. BECs were studied prerhinovirus-16 infection, postinfection, and post–inactivated rhinovirus-16 exposure. Cytokines and chemokines were measured. Viable cell numbers, numbers of apoptotic cells, and cell lysate caspase activity were used to measure apoptotic activity. Apoptotic activity inhibition using the caspase-3...

Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus

Rhinoviruses are the major trigger of acute asthma exacerbations and asthmatic subjects are more susceptible to these infections. To investigate the underlying mechanisms of this increased susceptibility, we examined virus replication and innate responses to rhinovirus (RV)-16 infection of primary bronchial epithelial cells from asthmatic and healthy control subjects. Viral RNA expression and l...